Nfia deletion in myeloid cells blocks expansion of myeloid-derived suppressor cells during sepsis:

Innate Immunity

JunDai¹ 

关键词: Sepsis;    immune suppression;    myeloid-derived suppressor cell;    NFI-A;   

DOI  :  10.1177/1753425917742956

学科分类：生物科学（综合）

来源: Sage Journals

【 摘 要 】

Sepsis-induced immunosuppression increases the risk of chronic infection and reduces survival. Myeloid-derived suppressor cells (MDSCs) expand in the bone marrow and spleen during murine polymicrobial sepsis, contributing to immunosuppression. A better understanding of molecular controls of MDSC production is needed to identify treatment targets. We previously reported that miR-21 and miR-181b couple with transcription factor NFI-A to induce MDSCs during murine sepsis. Here, we expand upon these observations by showing that conditional deletion of the Nfia gene in the myeloid lineage precludes MDSC development. NFI-A-deficient Gr1+CD11b+ myeloid cells are not immunosuppressive and differentiate normally into macrophages and dendritic cells. In contrast, ectopically expressed NFI-A prevents differentiation of these immature Gr1+CD11b+ cells, while converting them into MDSCs. In addition, NFI-A-deficient Gr1+CD11b+ cells decreased, and cells transfected with NFI-A increase expression of miR-21 and miR181b. ...

【 授权许可】

CC BY