Biomedical Applications of Quaternized Chitosan

Polymers

Aayush Sehgal¹  Tapan Behl¹  Sukhbir Singh¹  Simona Bungau²  Robert Gruszecki³  Agnieszka Najda³  Kamla Pathak⁴  Shashi Kiran Misra⁵ 

[1] Chitkara College of Pharmacy, Chitkara University, Rajpura 140401, India;Department of Pharmacy, Faculty of Medicine and Pharmacy, University of Oradea, 410028 Oradea, Romania;Department of Vegetable Crops and Medicinal Plants, University of Life Sciences in Lublin, 20-950 Lublin, Poland;Faculty of Pharmacy, Uttar Pradesh University of Medical Sciences, Etawah 206130, India;University Institute of Pharmacy, Chhatrapati Sahuji Maharaj University, Kanpur 208026, India;

关键词: quaternized chitosan;    antimicrobial;    biocompatibility;    biomedical;    vaccine;    wound healing;   

DOI  :  10.3390/polym13152514

来源: DOAJ

【 摘 要 】

The natural polymer chitosan is the second most abundant biopolymer on earth after chitin and has been extensively explored for preparation of versatile drug delivery systems. The presence of two distinct reactive functional groups (an amino group at C2, and a primary and secondary hydroxyl group at C3 and C6) of chitosan are involved in the transformation of expedient derivatives such as acylated, alkylated, carboxylated, quaternized and esterified chitosan. Amongst these, quaternized chitosan is preferred in pharmaceutical industries owing to its prominent features including superior water solubility, augmented antimicrobial actions, modified wound healing, pH-sensitive targeting, biocompatibility, and biodegradability. It has been explored in a large realm of pharmaceuticals, cosmeceuticals, and the biomedical arena. Immense classy drug delivery systems containing quaternized chitosan have been intended for tissue engineering, wound healing, gene, and vaccine delivery. This review article outlines synthetic techniques, basic characteristics, inherent properties, biomedical applications, and ubiquitous challenges associated to quaternized chitosan.

【 授权许可】

Unknown