Gross Morphological Variation in Preterm Placenta in Gestational Diabetes Mellitus and Pregnancy Induced Hypertension

Journal of Enam Medical College

关键词: Preterm Placenta;    GDM;    PIH;    Gross morphology;   

DOI  :  http://dx.doi.org/10.3329/jemc.v1i2.11466

来源: DOAJ

【 摘 要 】

Background: Preterm birth is the primary cause of perinatal mortality and morbidity.Recently, it has become a significant issue in public health policies of developing countries.Among the various causes, pregnancy induced hypertension (PIH) and Gestational diabetesmellitus (GDM) are two important high-risk factors for preterm birth. Again, placenta is amirror that reflects the well-being of the fetus and continuously undergoes a change in weight,structure, shape and function in order to support the well-being of the fetus. Objective: Tomake an in-depth analysis on the possible gross morphological changes in preterm placenta inrespect of GDM and PIH. Materials and Methods: The study was observational, analyticaland cross sectional. The patients under this study were selected from the Obstetric ward ofBSMMU and BIRDEM Hospital, from June 2005 to October 2005. A total of sixty-six sampleswere collected from women during 28 weeks to 36 completed weeks of gestation. Among them,twenty-two samples were from mothers having GDM, twenty-two having PIH and twenty-twobelonged to normal pregnancy (control group). The placentas were examined to measure theirdiameter, thickness, cotyledons number, weight, and volume. Results: In this study, the GDMgroup showed significantly higher values for the variables of diameter, weight, volume andnumber of cotyledons as compared to PIH group. On the other hand, the thickness of theplacenta showed lower values in GDM group, but the result did not reach a significant level. Conclusion: From the findings of this study, it is difficult to establish a clear-cut correlationabout placental changes in diabetic and hypertensive mothers during pregnancy. However, thechanges in placental weight, volume and diameter found in gestational diabetic mother may bea long term compensatory mechanism, aiming to secure a sufficient nutrient supply to supportthe growth of the foetus. So, postnatal examination of the placenta can yield information thatmay be important for immediate and late management of the mother and neonate.

【 授权许可】

Unknown