Maternal Prebiotic Ingestion Increased the Number of Fecal Bifidobacteria in Pregnant Women but Not in Their Neonates Aged One Month

Nutrients

Takayuki Toshimitsu¹  Naoko Ozawa¹  Takayuki Kubota¹  Fumiya Yamaide²  Taiji Nakano²  Yoshinori Morita²  Yoichi Kohno²  Naoki Shimojo²  Shuichi Suzuki²  Kentaro Masuda²  Takayasu Arima³  Yuka Igoshi⁴  Shinji Jinno⁴  Yoshitaka Nakamura⁴ 

[1] D Division, Meiji Co., Ltd., 540 Naruda, Odawaara Kanagawa 250-0862, Japan;Department of Pediatrics, Graduate School of Medicine, Chiba University, Chiba 260-8670, Japan;Department of Pediatrics, National Shimoshizu Hospital, Chiba 284-0003, Japan;;Food Science Research Laboratories, R&

关键词: fructooligosaccharides;    bifidobacteria;    feces;    infancy;    pregnancy;    prebiotic;    constipation;    stool frequency;   

DOI  :  10.3390/nu9030196

来源: DOAJ

【 摘 要 】

Fructooligosaccharides (FOS) can selectively stimulate the growth of bifidobacteria. Here, we investigated the effect of maternal FOS ingestion on maternal and neonatal gut bifidobacteria. In a randomized, double-blind, placebo-controlled study, we administered 8 g/day of FOS or sucrose to 84 women from the 26th week of gestation to one month after delivery. The bifidobacteria count was detected using quantitative PCR in maternal (26 and 36 weeks of gestation) and neonatal (one month after delivery) stools. Maternal stool frequency was recorded from 24 to 36 weeks of gestation. The number of fecal Bifidobacterium spp. and Bifidobacterium longum in the FOS group was significantly higher than that in the placebo group at 36 weeks of gestation (2.7 × 1010/g vs. 1.1 × 1010/g and 2.3 × 1010/g vs. 9.7 × 109/g). In their neonates, these numbers did not differ between the groups. Also, stool frequency in the FOS group was slightly higher than that in the placebo group two weeks after the intervention (1.0 vs. 0.8 times/day), suggesting a potential constipation alleviation effect. In conclusion, the maternal FOS ingestion showed a bifidogenic effect in pregnant women but not in their neonates.

【 授权许可】

Unknown