Environmental Exposure of Arsenic in Groundwater Associated to Carcinogenic Risk in Underweight Children Exposed to Fluorides

International Journal of Environmental Research and Public Health

Lizet Jarquin-Yañez¹  Enrique Castañeda²  Nelly Molina-Frechero²  Rey Gutiérrez-Tolentino²  Enrique Gaona²  Marcela Vergara-Onofre²  Martina Nevarez-Rascón³  Ronell Bologna-Molina⁴  Omar Tremillo-Maldonado⁴ 

[1] Center of Applied Research in Environment and Health, CIACYT, Universidad Autónoma de San Luis Potosí, San Luis Potosí 78120, Mexico;Division of Biological and Health Sciences, Universidad Autónoma Metropolitana, Mexico City 04460, Mexico;Faculty of Dentistry, Universidad Autónoma de Chihuahua, Chihuahua 31000, Mexico;Research Department, Faculty of Dentistry, Universidad Juárez del Estado de Durango, Durango 34000, Mexico;

关键词: arsenic;    exposure dose;    hazard quotient;    non-carcinogenic;    carcinogenic risk;   

DOI  :  10.3390/ijerph17030724

来源: DOAJ

【 摘 要 】

Background: The purpose of this study was to determine the concentration of inorganic arsenic (As) in the potable water available to the population to be able to estimate the non-carcinogenic risks for underweight children and the carcinogenic risk for adults exposed to As intake who live in the Mezquital municipality, Durango, Mexico. Methods: The As content was quantifed in the water supply sources for human use and its intake was estimated in Mezquital population, southern Durango. With the data obtained, the hazard quotient (HQ) was calculated to determine the non-carcinogenic risk to develop chronic systemic effects in underweight children. The Environmental Protection Agency (EPA) reference health values estimating As exposure risk are from 0.0003 mg/kg/day (non-carcinogenic) to 1.5 mg/kg/day (carcinogenic risk). Results: The analyzed waters presented as concentrations that varied from 0.3 to 10.2 µg/L, with a mean of 7.35 µg/L (CI 95% 6.27−8.38). The exposure dose was 0.4 to 1.36, and the HQ was 1.90 to 6.48 mg/kg/day, the estimated carcinogenic risk from adults varied from 1.28 to 4.37E⁻⁴, with values of 3.74−4.37E⁻⁴ mg/kg/day in central area. Conclusions: The children are at risk to develop chronic systemic effects due to ingestion of As from water.

【 授权许可】

Unknown