Novel Coordination Mode in the Potassium Mefenamate Trihydrate Polymeric Structure

Symmetry

Marta S. Krawczyk¹  Irena Majerz¹ 

[1] Faculty of Pharmacy, Wrocław Medical University, Borowska 211a, 50-556 Wrocław, Poland;

关键词: mefenamic acid;    potassium salt;    crystal structure;    QTAIM;    NCI approach;   

DOI  :  10.3390/sym13101761

来源: DOAJ

【 摘 要 】

As a result of the synthesis of mefenamic acid with potassium hydroxide, a salt with a polymeric structure is formed. The one-dimensional polymeric structure was studied by single crystal X-ray diffraction. The potassium cation is coordinated to one oxygen atom of the carboxylate group and six water oxygen atoms. Potassium ions are bridged by oxygen atoms of water molecules. The crystal structure was used as an input to QTAIM and NCI approaches to investigate the K-O interactions linking the cation with the water oxygen and carboxylate groups. The weak K-O interactions of the potassium cation and water oxygen atoms were strong enough to form a polymeric structure. The flexibility of the weak interactions is responsible for a novel coordination mode in the potassium mefenamate trihydrate.

【 授权许可】

Unknown