Design and synthesis of 1-aroyl-2-ylidene hydrazines under conventional and microwave irradiation conditions and their cytotoxic activities

Journal of the Brazilian Chemical Society

Lingam Venkata Reddy¹  Alishetty Suman¹  Syed Sultan Beevi²  Lakshmi Narasu Mangamoori²  Khagga Mukkanti¹  Sarbani Pal² 

[1] ,JNT University Centre for Environment Kukatpally,India

关键词: mefenamic acid;    hydrazine;    N-acylhydrazine;    microwave;    solvent-free synthesis;    cytotoxicity;   

DOI  :  10.1590/S0103-50532010000100015

来源: SciELO

【 摘 要 】

We report the design and synthesis of 1-aroyl-2-(alkenyl/aryl)idene hydrazines as hybrid molecules derived from mefenamic acid and substituted hydrazones. A number of compounds based on this new scaffold were prepared in good yields. The key intermediate N-acylhydrazine, prepared from mefenamic acid, was coupled with a variety of aldehydes under conventional as well as microwave irradiation conditions. The second approach, that requires short reaction time, can be carried out under a solvent free condition and does not require the use of an acid catalyst or solid support. Some of the compounds synthesized showed cytotoxic activities in vitro.

【 授权许可】

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