The Role of Platelets in the Tumor-Microenvironment and the Drug Resistance of Cancer Cells

Cancers

Duc-Hiep Bach¹  SangKook Lee¹  PhungThanh Huong²  Xuan-Bac Nguyen²  LapThi Nguyen² 

[1] College of Pharmacy, Natural Products Research Institute, Seoul National University, Seoul 08826, Korea;Department of Biochemistry, Hanoi University of Pharmacy, Hanoi 10000, Vietnam;

关键词: platelet;    drug resistance;    platelet-derived growth factor;    angiogenesis;    metastasis;    cancer biomarker;   

DOI  :  10.3390/cancers11020240

来源: DOAJ

【 摘 要 】

Besides the critical functions in hemostasis, thrombosis and the wounding process, platelets have been increasingly identified as active players in various processes in tumorigenesis, including angiogenesis and metastasis. Once activated, platelets can release bioactive contents such as lipids, microRNAs, and growth factors into the bloodstream, subsequently enhancing the platelet⁻cancer interaction and stimulating cancer metastasis and angiogenesis. The mechanisms of treatment failure of chemotherapeutic drugs have been investigated to be associated with platelets. Therefore, understanding how platelets contribute to the tumor microenvironment may potentially identify strategies to suppress cancer angiogenesis, metastasis, and drug resistance. Herein, we present a review of recent investigations on the role of platelets in the tumor-microenvironment including angiogenesis, and metastasis, as well as targeting platelets for cancer treatment, especially in drug resistance.

【 授权许可】

Unknown