Sensors and Biosensors for C-Reactive Protein, Temperature and pH, and Their Applications for Monitoring Wound Healing: A Review

Sensors

Arno Kirchhain¹  Tommaso Lomonaco¹  Fabio Di Francesco¹  Andrea Chiricozzi²  Agata Janowska²  Teresa Oranges²  Valentina Dini²  Marco Romanelli²  Pietro Salvo³ 

[1] Department of Chemistry and Industrial Chemistry, University of Pisa, Via Moruzzi 13, 56124 Pisa, Italy;Department of Dermatology, University of Pisa, Via Roma 67, 56126 Pisa, Italy;Institute of Clinical Physiology, National Council of Research (IFC-CNR), Via Moruzzi 1, 56124 Pisa, Italy;

关键词: C-reactive protein;    temperature;    pH;    sensors;    biosensors;    wound healing;   

DOI  :  10.3390/s17122952

来源: DOAJ

【 摘 要 】

Wound assessment is usually performed in hospitals or specialized labs. However, since patients spend most of their time at home, a remote real time wound monitoring would help providing a better care and improving the healing rate. This review describes the advances in sensors and biosensors for monitoring the concentration of C-reactive protein (CRP), temperature and pH in wounds. These three parameters can be used as qualitative biomarkers to assess the wound status and the effectiveness of therapy. CRP biosensors can be classified in: (a) field effect transistors, (b) optical immunosensors based on surface plasmon resonance, total internal reflection, fluorescence and chemiluminescence, (c) electrochemical sensors based on potentiometry, amperometry, and electrochemical impedance, and (d) piezoresistive sensors, such as quartz crystal microbalances and microcantilevers. The last section reports the most recent developments for wearable non-invasive temperature and pH sensors suitable for wound monitoring.

【 授权许可】

Unknown