Ipsilesional Mu Rhythm Desynchronization and Changes in Motor Behavior Following Post Stroke BCI Intervention for Motor Rehabilitation

Frontiers in Neuroscience

Brittany M. Young²  Rosaleena Mohanty³  Janerra Allen⁴  Justin C. Williams⁵  Vivek Prabhakaran⁶  Leroy Williams⁷  Matthew McMillan⁸  Keith Dodd⁸  Peter L. E. van Kan^1,10  Dorothy Farrar Edwards^1,10  Klevest Gjini^1,11  Theresa J. Kang^1,11  Shruti Rajan^1,12  Mohsen Mazrooyisebdani^1,13  Neelima Tellapragada^1,13  Veena A. Nair^1,13  Zack Nigogosyan^1,13  Hemali Advani^1,13  Matt Walczak^1,13  Alexander B. Remsik^1,14  Leo M. Walton^1,15  Jaclyn Thoma^1,15  Tyler Jacobson^1,15  Justin A. Sattin^1,15 

[1] 0Clinical Neuroengineering Training Program, University of Wisconsin–Madison, Madison, WI, United States;1Medical Scientist Training Program, University of Wisconsin School of Medicine and Public Health, Madison, WI, United States;2Department of Electrical and Computer Engineering, University of Wisconsin–Madison, Madison, WI, United States;3Department of Materials Science and Engineering, University of Wisconsin–Madison, Madison, WI, United States;4Department of Neurological Surgery, University of Wisconsin–Madison, Madison, WI, United States;5Department of Psychiatry, University of Wisconsin–Madison, Madison, WI, United States;Center for Women’s Health Research, University of Wisconsin–Madison, Madison, WI, United States;Department of Biomedical Engineering, University of Wisconsin–Madison, Madison, WI, United States;Department of Educational Psychology, University of Wisconsin–Madison, Madison, WI, United States;Department of Kinesiology, University of Wisconsin–Madison, Madison, WI, United States;Department of Neurology, University of Wisconsin–Madison, Madison, WI, United States;Department of Psychology, University of Wisconsin–Madison, Madison, WI, United States;Department of Radiology, University of Wisconsin–Madison, Madison, WI, United States;Institute for Clinical and Translational Research, University of Wisconsin–Madison, Madison, WI, United States;Neuroscience Training Program, University of Wisconsin School of Medicine and Public Health, Madison, WI, United States;

关键词: brain–computer interface;    hemiparesis;    r-squared;    coherence;    chronic;    acute;    neuroplasticity;    homunculus;   

DOI  :  10.3389/fnins.2019.00053

来源: DOAJ

【 摘 要 】

Loss of motor function is a common deficit following stroke insult and often manifests as persistent upper extremity (UE) disability which can affect a survivor’s ability to participate in activities of daily living. Recent research suggests the use of brain–computer interface (BCI) devices might improve UE function in stroke survivors at various times since stroke. This randomized crossover-controlled trial examines whether intervention with this BCI device design attenuates the effects of hemiparesis, encourages reorganization of motor related brain signals (EEG measured sensorimotor rhythm desynchronization), and improves movement, as measured by the Action Research Arm Test (ARAT). A sample of 21 stroke survivors, presenting with varied times since stroke and levels of UE impairment, received a maximum of 18–30 h of intervention with a novel electroencephalogram-based BCI-driven functional electrical stimulator (EEG-BCI-FES) device. Driven by spectral power recordings from contralateral EEG electrodes during cued attempted grasping of the hand, the user’s input to the EEG-BCI-FES device modulates horizontal movement of a virtual cursor and also facilitates concurrent stimulation of the impaired UE. Outcome measures of function and capacity were assessed at baseline, mid-therapy, and at completion of therapy while EEG was recorded only during intervention sessions. A significant increase in r-squared values [reflecting Mu rhythm (8–12 Hz) desynchronization as the result of attempted movements of the impaired hand] presented post-therapy compared to baseline. These findings suggest that intervention corresponds with greater desynchronization of Mu rhythm in the ipsilesional hemisphere during attempted movements of the impaired hand and this change is related to changes in behavior as a result of the intervention. BCI intervention may be an effective way of addressing the recovery of a stroke impaired UE and studying neuromechanical coupling with motor outputs.Clinical Trial Registration:ClinicalTrials.gov, identifier NCT02098265.

【 授权许可】

Unknown