Developing Modern Pain Therapies

Frontiers in Neuroscience

G. Gregory Neely¹  Teleri Clark²  Joshua N. Massingham²  John Manion²  Matthew A. Waller² 

[1] Genome Editing Initiative, The University of Sydney, Sydney, NSW, Australia;The Dr. John and Anne Chong Lab for Functional Genomics, Charles Perkins Centre and School of Life and Environmental Sciences, The University of Sydney, Sydney, NSW, Australia;

关键词: pain;    neuropathy;    inflammation;    dysfunctional;    analgesia;    cell therapy;   

DOI  :  10.3389/fnins.2019.01370

来源: DOAJ

【 摘 要 】

Chronic pain afflicts as much as 50% of the population at any given time but our methods to address pain remain limited, ineffective and addictive. In order to develop new therapies an understanding of the mechanisms of painful sensitization is essential. We discuss here recent progress in the understanding of mechanisms underlying pain, and how these mechanisms are being targeted to produce modern, specific therapies for pain. Finally, we make recommendations for the next generation of targeted, effective, and safe pain therapies.

【 授权许可】

Unknown