A New Approach to Synthesize of 4-Phenacylideneflavene Derivatives and to Evaluate Their Cytotoxic Effects on HepG2 Cell Line

Molecules

Yinan Zhang¹  Hongbin Chen²  Zongping Zheng²  Yang Xu³ 

[1] College of pharmacy, University of Kentucky, Lexington, KY 40536, USA;Fujian Province Key Laboratory for the Development of Bioactive Material from Marine Alge, College of Oceanology and Food Science, Quanzhou Normal University, Quanzhou 362000, China;School of Pharmaceutical Sciences, Xiamen University, Xiamen 361005, China;

关键词: substituted acetophenones;    2,4-dihydroxybenzaldehyde;    4-phenacylideneflavenes;    cytotoxic effect;    HepG2 cell line;   

DOI  :  10.3390/molecules22081296

来源: DOAJ

【 摘 要 】

In this study, a convenient approach and green procedure for the synthesis of 4-phenacylideneflavenes has been developed from the reaction between 2,4-dihydroxybenzaldehyde and substituted acetophenones using boric acid as a catalyst in polyethylene glycol 400. Seven 4-phenacylideneflavenes were synthetized and their structures were confirmed by NMR and mass spectral analyses. Meanwhile, their possible mechanism of formation was also discussed. These products were found to have potential cytotoxic effect on HepG2 cell line with IC50 values from 12.5 to 50 µM.

【 授权许可】

Unknown