The radioprotective effect of a new aminothiol (20-PRA)

Brazilian Journal of Medical and Biological Research

M.f. Dolabela²  M.t. Pereira¹  C.e. Salas¹  G.m. Steffani¹  D.l. Nelson¹  D. Piló-veloso¹  M.t.p. Lopes² 

[1] ,Universidade Federal de Minas Gerais

关键词: aminothiols;    cytotoxic effect;    radioprotector;    antitumorigenic effect;   

DOI  :  10.1590/S0100-879X1998000800010

来源: SciELO

【 摘 要 】

We examined the radioprotective effect of aminothiol 2-N-propylamine-cyclo-hexanethiol (20-PRA) on a human leukemic cell line (K562) following various radiation doses (5, 7.5 and 20 Gy) using a source of 60Co g-rays. At 5 Gy and 1 nM 20-PRA, a substantial protective effect (58%) was seen 24 h after irradiation, followed by a decrease at 48 h (11%). At the high radiation dose (20 Gy) a low protective effect was also seen (35%). In addition, the antitumorigenic potential of 10 nM 20-PRA was shown by the inhibition of crown gall formation induced by Agrobacterium tumefaciens. The radioprotective potency of 20-PRA is 105-106 times higher than that of the aminothiol WR-1065 (N-(2-mercaptoethyl)-1,3-diaminopropane) whose protective effect is in the 0.1 to 1.0 mM range.

【 授权许可】

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