Building and breaking the gut barrier with bariatric surgery

Cell Stress

Mohammed K. Hankir¹ 

[1] Department of Experimental Surgery, University Hospital Wuerzburg, Wuerzburg, 97080, Germany.;

关键词: bariatric surgery;    gut barrier;    gut microbiota;    insulin resistance;    endotoxemia;   

DOI  :  10.15698/cst2022.02.263

来源: DOAJ

【 摘 要 】

Bariatric surgery has been proposed to improve glycemic control in morbidly obese patients by stabilising the gut barrier and alleviating endotoxemia-induced insulin resistance. Here, recent studies are highlighted which reveal site-specific and at times opposing effects of bariatric surgery on the gut barrier. Further understanding the underlying mechanisms may not only inform the development of novel gut-based drugs for the initial treatment of type 2 diabetes, but possibly also assist in the management of its eventual relapse.

【 授权许可】

Unknown