Synthesis, Characterization and Biological Evaluation of Newer Chalcones by Microwave irradiation

To Chemistry Journal

Rajendra P.Pawar¹  Shrikrishna Tupare² 

[1] Department of Chemistry, Deogiri College, Aurangabad-431005, MS, India;Department of Chemistry, K. E. S. Anandibai Pradhan Science College, Nagothane- 402106, MS, India;

关键词: Pyridazine;    Microwave;    Chalcones;    Antifungal;    Antibacterial;    Acetophenone;   

DOI  :  

来源: DOAJ

【 摘 要 】

Chalcones are a common natural pigment & one of the most important classes of flavonoids & iso-flavonoids across the whole edible plant kingdom. This α, β- unsaturated carbonyl is an important and versatile intermediate for the preparation of various heterocycles. Their utility lies in their usefulness as synthons. Many research articles on chalcones were found in the literature. In this article, a series of pyridazine Chalcone derivatives were synthesized by Claisen-Schmidt condensation of 6-(3-Acetyl phenylamino) pyridazin-3(2H)-one with substituted benzaldehyde with potassium hydroxide in microwave assessed irradiation. All the synthesized derivatives(3a-o) were screened for their anti-bacterial and anti-fungal activities. Several compounds throughout the series showed moderate to good anti-bacterial and anti-fungal activity against human pathogens.

【 授权许可】

Unknown