期刊论文详细信息
Molecules | |
Polyfunctional Nitriles in Organic Syntheses: A Novel Route to Aminopyrroles, Pyridazines and Pyrazolo[3,4-c]pyridazines | |
关键词: Aminopyrrole; Pyridazine; Pyrazolopyridazine; Phenacylmalononitrile; | |
DOI : 10.3390/molecules14020798 | |
来源: DOAJ |
【 摘 要 】
Phenacylmalononitrile 1 reacts with dimethylformamide dimethyl acetal to yield an enaminone which could be readily converted into a pyrrole or an aminopyridazine by treating with ammonium acetate and hydrazine hydrate, respectively. Compound 1 reacted with hydrazine hydrate in ethanol at room temperature to yield the dihydropyridazine 9 as a single product. In refluxing ethanol this product further reacted with hydrazine hydrate to yield the novel dihydropyrazolopyridazinamine 10.
【 授权许可】
Unknown