Diagnostic value of whole-body MRI in Opsoclonus-myoclonus syndrome: a clinical case series (3 case reports)

BMC Medical Imaging

Rupert Handgretinger¹  Roland Bares²  Martin Ebinger³  Corinna Storz⁴  Jürgen F. Schäfer⁴  Ilias Tsiflikas⁴ 

[1] Department of Hematology/Oncology, Children’s University Hospital Tuebingen;Department of Nuclear Medicine and Clinical Molecular Imaging, University Hospital Tuebingen;Department of Pediatric Surgery, Children’s University Hospital Tuebingen;Division of Pediatric Radiology, Department of Diagnostic and Interventional Radiology, University Hospital Tuebingen;

关键词: Whole-body MRI;    Scintigraphy;    Neuroblastoma;    Opsoclonus-myoclonus syndrome;   

DOI  :  10.1186/s12880-019-0372-y

来源: DOAJ

【 摘 要 】

Abstract Background Opsoclonus-myoclonus syndrome (OMS) is a rare clinical disorder and typically occurs in association with occult neuroblastic tumor in pediatric patients. I-123 metaiodobenzylguanidine (mIBG) scintigraphy is widely adopted as screening procedure in patients with suspected neuroblastic tumor. Also, contrast-enhanced magnetic resonance imaging (MRI) or computed tomography (CT) are involved in the imaging workup, primarily for the assessment of the primary tumor region. However, the diagnostic value of whole-body MRI (WB-MRI) for the detection of occult neuroblastic tumor in pediatric patients presenting with OMS remains unknown. Case presentation We present three cases of patients with OMS, in whom WB-MRI revealed occult neuroblastic tumor masses, whereas scintigraphy was inconclusive: In a 17 months old girl with OMS, WB-MRI revealed a paravertebral mass. After thoracoscopic resection, histopathology revealed a ganglioneuroblastoma. A 13 months old boy presenting with OMS WB-MRI detected a tumor of the left adrenal gland; histopathology demonstrated a ganglioneuroblastoma after adrenalectomy. In a 2 year old boy with OMS, immunoscintigraphy at the time of diagnosis was inconclusive. At the age of 13 years, a WB-MRI was performed due to persistent neurological symptoms, revealing a paravertebral retroperitoneal mass, which was classified as ganglioneuroblastoma. Conclusion In OMS, particularly in the setting of inconclusive scintigraphy, WB-MRI may be considered as a valuable alternative in the early phase of diagnostic work-up.

【 授权许可】

Unknown