Gut microbiome composition in the Hispanic Community Health Study/Study of Latinos is shaped by geographic relocation, environmental factors, and obesity

Genome Biology

Rob Knight¹  Daniela Sotres-Alvarez²  Zheng Wang³  Jee-Young Moon³  Qibin Qi³  Tao Wang³  Robert C. Kaplan³  Carmen R. Isasi³  Robert D. Burk³  Kari E. North⁴  Mykhaylo Usyk⁵  Christopher C. Sollecito⁵  Justin Shaffer⁶  Daniel McDonald⁶  Marc D. Gellman⁷  Neil Schneiderman⁷  Gregory A. Talavera⁸  Bharat Thyagarajan⁹  Michael C. Wu^1,10  Jessica S. Williams-Nguyen^1,10  Martha L. Daviglus^1,11  Yoshiki Vázquez-Baeza^1,12 

[1] Center for Microbiome Innovation, University of California;Department of Biostatistics, Gillings School of Global Public Health, University of North Carolina;Department of Epidemiology and Population Health, Albert Einstein College of Medicine;Department of Epidemiology, Gillings School of Global Public Health, University of North Carolina;Department of Pediatrics, Albert Einstein College of Medicine;Department of Pediatrics, University of California;Department of Psychology, University of Miami;Division of Health Promotion and Behavioral Science, San Diego State University;Division of Molecular Pathology and Genomics, University of Minnesota;Division of Public Health Sciences, Fred Hutchinson Cancer Research Center;Institute for Minority Health Research, University of Illinois at Chicago College of Medicine;Jacobs School of Engineering, University of California;

关键词: Microbiome;    Epidemiology;    Hispanic population;    Mycobiome;    Obesity;   

DOI  :  10.1186/s13059-019-1831-z

来源: DOAJ

【 摘 要 】

Abstract Background Hispanics living in the USA may have unrecognized potential birthplace and lifestyle influences on the gut microbiome. We report a cross-sectional analysis of 1674 participants from four centers of the Hispanic Community Health Study/Study of Latinos (HCHS/SOL), aged 18 to 74 years old at recruitment. Results Amplicon sequencing of 16S rRNA gene V4 and fungal ITS1 fragments from self-collected stool samples indicate that the host microbiome is determined by sociodemographic and migration-related variables. Those who relocate from Latin America to the USA at an early age have reductions in Prevotella to Bacteroides ratios that persist across the life course. Shannon index of alpha diversity in fungi and bacteria is low in those who relocate to the USA in early life. In contrast, those who relocate to the USA during adulthood, over 45 years old, have high bacterial and fungal diversity and high Prevotella to Bacteroides ratios, compared to USA-born and childhood arrivals. Low bacterial diversity is associated in turn with obesity. Contrasting with prior studies, our study of the Latino population shows increasing Prevotella to Bacteroides ratio with greater obesity. Taxa within Acidaminococcus, Megasphaera, Ruminococcaceae, Coriobacteriaceae, Clostridiales, Christensenellaceae, YS2 (Cyanobacteria), and Victivallaceae are significantly associated with both obesity and earlier exposure to the USA, while Oscillospira and Anaerotruncus show paradoxical associations with both obesity and late-life introduction to the USA. Conclusions Our analysis of the gut microbiome of Latinos demonstrates unique features that might be responsible for health disparities affecting Hispanics living in the USA.

【 授权许可】

Unknown