Microbial co-occurrence complicates associations of gut microbiome with US immigration, dietary intake and obesity

Genome Biology

Rob Knight¹  Yoshiki Vázquez-Baeza²  Simin Hua³  Carmen R. Isasi³  Tao Wang³  Guo-Chong Chen³  Zheng Wang³  Qibin Qi⁴  Robert D. Burk⁵  Robert C. Kaplan⁶  Daniel McDonald⁷  Mykhaylo Usyk⁸  Jessica S. Williams-Nguyen⁹  Martha L. Daviglus^1,10  Bharat Thyagarajan^1,11  Jianwen Cai^1,12  Kari E. North^1,12 

[1] Center for Microbiome Innovation, University of California, San Diego, La Jolla, CA, USA;Department of Pediatrics, University of California, San Diego, La Jolla, CA, USA;Department of Bioengineering, University of California, San Diego, La Jolla, CA, USA;Department of Computer Science and Engineering, University of California, San Diego, La Jolla, CA, USA;Center for Microbiome Innovation, University of California, San Diego, La Jolla, CA, USA;Jacobs School of Engineering, University of California, San Diego, La Jolla, CA, USA;Department of Epidemiology and Population Health, Albert Einstein College of Medicine, 1300 Morris Park Avenue, 10461, Bronx, NY, USA;Department of Epidemiology and Population Health, Albert Einstein College of Medicine, 1300 Morris Park Avenue, 10461, Bronx, NY, USA;Department of Nutrition, Harvard T.H. Chan School of Public Health, Boston, MA, USA;Department of Epidemiology and Population Health, Albert Einstein College of Medicine, 1300 Morris Park Avenue, 10461, Bronx, NY, USA;Department of Obstetrics & Gynecology and Women’s Health, Albert Einstein College of Medicine, Bronx, NY, USA;Department of Microbiology & Immunology, Albert Einstein College of Medicine, Bronx, NY, USA;Department of Epidemiology and Population Health, Albert Einstein College of Medicine, 1300 Morris Park Avenue, 10461, Bronx, NY, USA;Public Health Sciences Division, Fred Hutchinson Cancer Research Center, Seattle, WA, USA;Department of Pediatrics, University of California, San Diego, La Jolla, CA, USA;Departments of Pediatrics, Albert Einstein College of Medicine, Bronx, New York, USA;Public Health Sciences Division, Fred Hutchinson Cancer Research Center, Seattle, WA, USA;University of Illinois at Chicago, Chicago, IL, USA;University of Minnesota Medical Center, Minneapolis, MN, USA;University of North Carolina at Chapel Hill, Chapel Hill, NC, USA;

关键词: Microbiome;    Metagenomics;    Hispanic population;    Obesity;   

DOI  :  10.1186/s13059-021-02559-w

来源: Springer

【 摘 要 】

BackgroundObesity and related comorbidities are major health concerns among many US immigrant populations. Emerging evidence suggests a potential involvement of the gut microbiome. Here, we evaluated gut microbiome features and their associations with immigration, dietary intake, and obesity in 2640 individuals from a population-based study of US Hispanics/Latinos.ResultsThe fecal shotgun metagenomics data indicate that greater US exposure is associated with reduced ɑ-diversity, reduced functions of fiber degradation, and alterations in individual taxa, potentially related to a westernized diet. However, a majority of gut bacterial genera show paradoxical associations, being reduced with US exposure and increased with fiber intake, but increased with obesity. The observed paradoxical associations are not explained by host characteristics or variation in bacterial species but might be related to potential microbial co-occurrence, as seen by positive correlations among Roseburia, Prevotella, Dorea, and Coprococcus. In the conditional analysis with mutual adjustment, including all genera associated with both obesity and US exposure in the same model, the positive associations of Roseburia and Prevotella with obesity did not persist, suggesting that their positive associations with obesity might be due to their co-occurrence and correlations with obesity-related taxa, such as Dorea and Coprococcus.ConclusionsAmong US Hispanics/Latinos, US exposure is associated with unfavorable gut microbiome profiles for obesity risk, potentially related to westernized diet during acculturation. Microbial co-occurrence could be an important factor to consider in future studies relating individual gut microbiome taxa to environmental factors and host health and disease.

【 授权许可】

CC BY