Educational Setting and SARS-CoV-2 Transmission Among Children With Multisystem Inflammatory Syndrome: A French National Surveillance System

Frontiers in Pediatrics

Noémie Lachaume¹  Arnaud Wiedemann²  Marie-Laure Girardin⁴  Alexis Rybak⁵  Etienne Javouhey⁶  Mathie Lorrot⁷  Alexandre Belot⁸  David Dawei Yang⁹  Michael Levy^1,10  Caroline Galeotti^1,11  Caroline Ovaert^1,13  Robert Cohen^1,15  Corinne Levy^1,15  Marion Caseris^1,17  Mehdi Oualha^1,18  Fouad Madhi^1,19  Julie Toubiana^2,21  Denise Antona^2,22  Celia Guenver^2,23 

[1] 0Assistance Publique-Hôpitaux de Paris, Paediatric Emergency Department, Louis Mourier University Hospital, Colombes, France;0INSERM UMRS 1256 NGERE, Nutrition, Genetics, and Environmental Risk Exposure, National Center of Inborn Errors of Metabolism, Université de Lorraine, Vandoeuvre les Nancy, France;1Hospices Civils de Lyon, Paediatric Intensive Care Unit, Hopital Femme, Mère Enfant, University of Lyon, Le Born, France;1Strasbourg University Hospital, Paediatric Intensive Care Unit, Hautepierre University Hospital, Strasbourg, France;2Assistance Publique-Hôpitaux de Paris, Pediatric Emergency Department, Robert Debré University Hospital, Université de Paris, Paris, France;2EA 7426 “Pathophysiology of Injury-Induced Immunosuppression”, University Claude Bernard Lyon 1, Hospices Civils of Lyon, Lyon, France;3Assistance Publique-Hôpitaux de Paris, Department of General Paediatric, Armand Trousseau University Hospital, Sorbonne Université, Paris, France;;3Hospices Civils de Lyon, Paediatric Nephrology, Rheumatology, Dermatology, Hopital Femme, Mère Enfant, &4Assistance Publique-Hôpitaux de Paris, Paediatric Emergency Department, Necker-Enfants Malades University Hospital, Université de Paris, Paris, France;5Assistance Publique-Hôpitaux de Paris, Paediatric Intensive Care Unit, Robert Debré University Hospital, Université de Paris, Paris, France;6Assistance Publique-Hôpitaux de Paris, Department of Paediatric Rheumatology, Reference Centre for Autoinflammatory Diseases and Amyloidosis (CEREMAIA), Bicêtre University hospital, Université de Paris Saclay, Le Kremlin-Bicêtre, France;7Assistance Publique-Hôpitaux de Marseille, Paediatric and Congenital Cardiology, Timone Hospital Marseille, University Hospital, Marseille, France;8INSERM, Marseille Medical Genetics, UMR 1251, Aix Marseille Université, Marseille, France;9Children's Hospital, University Hospital of Nancy, Paediatric Department, Université de Lorraine, Vandoeuvre les Nancy, France;ACTIV, Association Clinique et Thérapeutique Infantile du Val-de-Marne, Créteil, France;Assistance Publique-Hôpitaux de Paris, Department of General Paediatrics and Paediatric Infectious Diseases, Necker-Enfants-Malades University Hospital, Université de Paris, Paris, France;Assistance Publique-Hôpitaux de Paris, Department of General Paediatrics, Paediatric Infectious Disease and Internal Medicine, Robert Debré University Hospital, Université de Paris, Paris, France;Assistance Publique-Hôpitaux de Paris, Paediatric Intensive Care Unit, Necker-Enfants Malades University Hospital, Université de Paris, Paris, France;Centre Hospitalier Intercommunal, Paediatric Department, Université Paris Est, IMRB-GRC GEMINI, Créteil, France;Centre Hospitalier Intercommunal, Research Centre, Université Paris Est, IMRB-GRC GEMINI, Créteil, France;Institut Pasteur, Biodiversity and Epidemiology of Bacterial Pathogens, Paris, France;Santé Publique France, Agence nationale de Santé publique, Saint-Maurice, France;Sorbonne Université, Université de Paris, Paris, France;

关键词: multisystem inflammatory syndrome in children (MIS-C);    educational setting;    SARS-CoV-2;    school;    pediatrics-children;   

DOI  :  10.3389/fped.2021.745364

来源: DOAJ

【 摘 要 】

Background: Multisystem inflammatory syndrome in children (MIS-C) is the most severe form associated with SARS-CoV-2 infection in children. To reduce the spread of SARS-CoV-2 at the population level, educational setting closure have been implemented in many countries. However, the direct benefit of school closure on the MIS-C burden remains to be explored. We aimed to assess the role of educational settings in SARS-CoV-2 transmission among children with MIS-C.Methods: We conducted a French national prospective surveillance of MIS-C, coordinated by Public Health France, from April 2020 to March 2021. During this period, we included all children with MIS-C fulfilling the WHO definition who were reported to Public Health France. For each child, we traced the source of SARS-CoV-2 transmission. The main outcome was the proportion of children with MIS-C, with educational setting-related SARS-CoV-2 infection, during the period of school opening.Results: We included 142 children fulfilling WHO criteria for MIS-C: 104 (70%) cases occurred during school opening periods. In total, 62/104 children (60%, 95%CI [50; 69]) had been contaminated by a household contact and 5/104 in educational settings (5%, 95%CI [2; 11]). Among children with MIS-C occurring during school closure periods, the proportion of household transmission remained similar (66%, 25/38).Conclusion: Children with MIS-C were mainly infected by SARS-CoV-2 within their family environment, and the educational setting played a marginal role in this transmission. This suggests that mitigating school attendance may not reduce substantially the burden of MIS-C.

【 授权许可】

Unknown