Loss of p16: A Bouncer of the Immunological Surveillance?

Life

KatherineM. Aird¹  KellyE. Leon¹  NaveenKumar Tangudu¹  Raquel Buj¹ 

[1] UPMC Hillman Cancer Center, Department of Pharmacology & Chemical Biology, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213, USA;

关键词: senescence-associated secretory phenotype (SASP);    senescence;    cell-cycle;    melanoma;    pancreatic adenocarcinoma;    tumor infiltration;   

DOI  :  10.3390/life11040309

来源: DOAJ

【 摘 要 】

p16^INK4A (hereafter called p16) is an important tumor suppressor protein frequently suppressed in human cancer and highly upregulated in many types of senescence. Although its role as a cell cycle regulator is very well delineated, little is known about its other non-cell cycle-related roles. Importantly, recent correlative studies suggest that p16 may be a regulator of tissue immunological surveillance through the transcriptional regulation of different chemokines, interleukins and other factors secreted as part of the senescence-associated secretory phenotype (SASP). Here, we summarize the current evidence supporting the hypothesis that p16 is a regulator of tumor immunity.

【 授权许可】

Unknown