Effects of a lupin protein concentrate on lipids, blood pressure and insulin resistance in moderately dyslipidaemic patients: A randomised controlled trial

Journal of Functional Foods

Cesare R. Sirtori¹  Anna Arnoldi¹  Giuliana Mombelli²  Chiara Pavanello³  Laura Calabresi³  Paolo Magni³  Carmen Lammi⁴  Chiara Zanoni⁴  Massimiliano Ruscica⁵  Raffaella Bosisio⁵ 

[1] Dipartimento di Scienze Farmacologiche e Biomolecolari, Università degli Studi di Milano, Milan, Italy;Centro Dislipidemie, A.S.S.T. Grande Ospedale Metropolitano Niguarda, Milan, Italy;Centro Grossi Paoletti, Dipartimento di Scienze Farmacologiche e Biomolecolari, Università degli Studi di Milano, Milan, Italy;Dipartimento di Scienze Farmaceutiche, Università degli Studi di Milano, Milan, Italy;Dipartimento di Scienze Farmacologiche e Biomolecolari, Università degli Studi di Milano, Milan, Italy;

关键词: Lupin protein;    Lipids;    PCSK9;    Blood pressure;    Glycaemic control;   

DOI  :  

来源: DOAJ

【 摘 要 】

The study had the objective of evaluating the effects of a lupin protein concentrate on plasma lipids and other cardiovascular risk factors, e.g. blood pressure and insulin resistance, compared to a skimmed milk powder. Fifty subjects followed a randomised, parallel, double-blind, single-centre study, consisting in a 12-week intervention: half of the participants consumed a lupin protein concentrate (30 g/day of protein), the other half a lactose-free skimmed milk powder (30 g/day of protein), both integrated into a mixed low-lipid diet. At the end of intervention, both groups showed similar reductions of total cholesterol concentrations versus baseline (−6.7%, and −7.2%, respectively), but the reductions of LDL-cholesterol (−8.0%), non-HDL-cholesterol (−7.5%), and proprotein convertase subtilisin/kexin type 9 (PCSK9) (−12.7%) levels were statistically significant only after the lupin diet. A significant reduction of HDL-cholesterol concentration was observed only after the milk diet. The differences between the two groups, however, were not statistically significant.

【 授权许可】

Unknown