Synthesis and Analgesic Activity Evaluation of Some Agmatine Derivatives

Molecules

关键词: Agmatine derivatives;    synthesis;    analgesic activity;    blood-brain barrier;    opioid dependence.;   

DOI  :  10.3390/11060393

来源: DOAJ

【 摘 要 】

A series of N,N’-disubstituted-2-nitroethene-1,1-diamine and N,N’-disubstituted- N’’-cyanoguanidine derivatives were prepared and evaluated for in vivo analgesic activity. The blood brain barrier (BBB) VolSurf model was used to predict the BBB permeation profiles of our synthesized compounds. Some compounds show both remarkable analgesic activity and good BBB permeation profiles, and these compounds might be developed for treatment of opioid tolerance and dependence.

【 授权许可】

Unknown