Cellular and Molecular Responses to Mechanical Expansion of Tissue

Frontiers in Physiology

Md. Sanower Hossain¹  Muhammad Abdur Razzak¹  Noor Azlin Yahya¹  Mohammad Tariqur Rahman¹  Zamri Radzi¹  Jan Czernuszka² 

[1] University Malaya;University of Oxford;

关键词: Apoptosis;    Ion Channels;    Tissue Expansion;    growth factors;    Focal adhesion complex;    secondary messengers.;   

DOI  :  10.3389/fphys.2016.00540

来源: DOAJ

【 摘 要 】

The increased use of tissue expander in the past decades and its potential market values in near future give enough reasons to sum up the consequences of tissue expansion. Furthermore, the patients have the right to know underlying mechanisms of adaptation of inserted biomimetic, its bioinspired materials and probable complications. The mechanical strains during tissue expansion are related to several biological phenomena. Tissue remodelling during the expansion is highly regulated and depends on the signal transduction. Any alteration may lead to tumour formation, necrosis and/or apoptosis. In this review, stretch induced cell proliferation, apoptosis, the roles of growth factors, stretch induced ion channels, and roles of second messengers are organized. It is expected that readers from any background can understand and make a decision about tissue expansion.

【 授权许可】

Unknown