Risk factors of accelerated progression of peripheral artery disease in hemodialysis

Kaohsiung Journal of Medical Sciences

Ho-Ming Su¹  Shang-Reu Hsu²  Ming-Chia Hsieh²  Shin-Li Su²  Hung-Chun Chen³  Szu-Chia Chen³ 

[1] Division of Cardiology, Department of Internal Medicine, Kaohsiung Medical University Hospital, Kaohsiung Medical University, Kaohsiung, Taiwan;Division of Endocrinology and Metabolism, Department of Medical, Changhua Christian Hospital, Changhua, Taiwan;Division of Nephrology, Department of Internal Medicine, Kaohsiung Medical University Hospital, Kaohsiung Medical University, Kaohsiung, Taiwan;

关键词: Ankle-brachial index;    Arterial stiffness;    Brachial-ankle pulse wave velocity;    Hemodialysis;    Peripheral artery occlusive disease;   

DOI  :  10.1016/j.kjms.2012.08.014

来源: DOAJ

【 摘 要 】

Ankle-brachial index (ABI) and brachial-ankle pulse wave velocity (baPWV) are markers for peripheral artery occlusive disease (PAOD) and arterial stiffness, respectively. The aims of this study were to assess whether PAOD and arterial stiffness progressed and to determine the risk factors for ABI and baPWV progression in patients on hemodialysis. This study enrolled 173 routine patients on hemodialysis. Both ABI and baPWV were measured by an ABI-form device at baseline and at 1 year of follow-up. Progression in ABI was defined as reduction in ABI exceeding 0.3, while baPWV measured at 1 year of follow-up exceeding that at baseline indicated baPWV progression. Comparison with baseline data showed increase in both prevalence of ABI < 0.9 (p = 0.045) and baPWV (p = 0.028) at 1 year of follow-up. Multiple linear regression analyses identified high fasting glucose and old age as independent factors of annual change in ABI and baPWV, respectively. Good control of blood sugar may contribute to delay the progression of peripheral artery disease in patients on hemodialysis.

【 授权许可】

Unknown