Molecular Profile Study of Extracellular Vesicles for the Identification of Useful Small “Hit” in Cancer Diagnosis

Applied Sciences

Giusi Alberti¹  Claudia Campanella¹  Francesco Cappello¹  Radha Santonocito¹  Alexia Andres²  Christian M. Sánchez-López³  Antonio Marcilla³ 

[1] Department of Biomedicine, Neurosciences and Advanced Diagnostics (BiND), University of Palermo, 90127 Palermo, Italy;Joint Unit of Endocrinology, Nutrition and Clinical Dietetics, Instituto de Investigación Sanitaria-La Fe, 46026 Valencia, Spain;Área de Parasitología, Departamento Farmacia y Tecnología Farmacéutica y Parasitología, F. Farmacia, Universitat de València, 46100 Burjassot, Spain;

关键词: extracellular vesicles;    liquid biopsy;    biomarkers;    tumor progression;    metastasis;   

DOI  :  10.3390/app112210787

来源: DOAJ

【 摘 要 】

Tumor-secreted extracellular vesicles (EVs) are the main mediators of cell-cell communication, permitting cells to exchange proteins, lipids, and metabolites in varying physiological and pathological conditions. They contain signature tumor-derived molecules that reflect the intracellular status of their cell of origin. Recent studies have shown that tumor cell-derived EVs can aid in cancer metastasis through the modulation of the tumor microenvironment, suppression of the immune system, pre-metastatic niche formation, and subsequent metastasis. EVs can easily be isolated from a variety of biological fluids, and their content makes them useful biomarkers for the diagnosis, prognosis, monitorization of cancer progression, and response to treatment. This review aims to explore the biomarkers of cancer cell-derived EVs obtained from liquid biopsies, in order to understand cancer progression and metastatic evolution for early diagnosis and precision therapy.

【 授权许可】

Unknown