Smart Bandage Based on Molecularly Imprinted Polymers (MIPs) for Diclofenac Controlled Release

Pharmaceuticals

OrtensiaIlaria Parisi¹  Luca Scrivano¹  Mariarosa Ruffo¹  Francesco Puoci¹  Rocco Malivindi¹  Antonio Vassallo² 

[1] Department of Pharmacy, Health and Nutritional Sciences, University of Calabria, 87036 Rende (CS), Italy;Department of Science, University of Basilicata, 85100 Potenza, Italy;

关键词: Molecularly Imprinted Polymers (MIPs);    Diclofenac;    controlled release;    smart bandage;    in vitro diffusion studies;    adsorption and release kinetics;    skin irritation;    precipitation polymerization;   

DOI  :  10.3390/ph11040092

来源: DOAJ

【 摘 要 】

The aim of the present study was the development of a “smart bandage” for the topical administration of diclofenac, in the treatment of localized painful and inflammatory conditions, incorporating Molecularly Imprinted Polymers (MIPs) for the controlled release of this anti-inflammatory drug. For this purpose, MIP spherical particles were synthesized by precipitation polymerization, loaded with the therapeutic agent and incorporated into the bandage surface. Batch adsorption binding studies were performed to investigate the adsorption isotherms and kinetics and the selective recognition abilities of the synthesized MIP. In vitro diffusion studies were also carried out using Franz cells and the obtained results were reported as percentage of the diffused dose, cumulative amount of diffused drug, steady-state drug flux and permeability coefficient. Moreover, the biocompatibility of the developed device was evaluated using the EPISKIN™ model. The Scatchard analysis indicated that the prepared MIP is characterized by the presence of specific binding sites for diclofenac, which are not present in the corresponding non-imprinted polymer, and the obtained results confirmed both the ability of the prepared bandage to prolong the drug release and the absence of skin irritation reactions. Therefore, these results support the potential application of the developed “smart bandage” as topical device for diclofenac sustained release.

【 授权许可】

Unknown