Diclofenac as a factor in the change of Rhodococcus metabolism

2nd International (15th Regional) Scientific Conference "Technogenic Systems and Environmental Risk"

工业技术（总论）;生态环境科学

Tyumina, E.A.^1 ; Bazhutin, G.A.^2 ; Vikhareva, E.V.^3 ; Selyaninov, A.A.^4 ; Ivshina, I.B.^1^5

Perm State National Research University, Perm, Russia^1

Perm State Humanitarian Pedagogical University, Perm, Russia^2

Perm State Pharmaceutical Academy, Perm, Russia^3

Perm State National Research Polytechnic University, Perm, Russia^4

Institute of Ecology and Genetics of Microorganisms, Ural Branch Russian Academy of Sciences, Perm, Russia^5

关键词: Actinobacteria;    Diclofenac;    Morphometric characteristics;    Non-steroidal anti-inflammatory drugs;    Rhodococcus;    Sodium salt;   

Others  :  https://iopscience.iop.org/article/10.1088/1757-899X/487/1/012027/pdf
DOI  :  10.1088/1757-899X/487/1/012027

来源: IOP

【 摘 要 】

The non-steroidal anti-inflammatory drug diclofenac (2-[2-(2,6-dichloroanilino)phenyl] acetic acid) is one of the most frequently detected pharmaceuticals in the environment. The ability of actinobacteria of the genus Rhodococcus to biodegrade diclofenac (170 μ) as the sodium salt has been revealed. Cells of R. ruber IEGM 231 pregrown with diclofenac (1.7 μ) removed diclofenac (about 50% degradation) within 56 days in the presence of glucose. Diclofenac induced changes in the morphometric characteristics of rhodococci. The products of diclofenac biodegradation did not have pronounced phytotoxicity.