Potential Clinical Applications of the Postbiotic Butyrate in Human Skin Diseases

Molecules

Antonio Calignano¹  Antonia Sacchi¹  Sonia Laneri¹  Carmen Avagliano¹  Roberto Berni Canani²  Serena Coppola²  Anna Luzzetti²  Luana Voto² 

[1] Department of Pharmacy, University of Naples Federico II, Via Domenico Montesano 49, 80131 Napoli, Italy;Department of Translational Medical Science, University of Naples Federico II, Via Sergio Pansini 5, 80131 Naples, Italy;

关键词: short chain fatty acids;    skin microbiome;    skin barrier;    atopic dermatitis;    psoriasis;    UVB radiation;   

DOI  :  10.3390/molecules27061849

来源: DOAJ

【 摘 要 】

Human skin is the largest organ and the most external interface between the environment and the body. Vast communities of viruses, bacteria, archaea, fungi, and mites, collectively named the skin microbiome (SM), cover the skin surface and connected structures. Skin-resident microorganisms contribute to the establishment of cutaneous homeostasis and can modulate host inflammatory responses. Imbalances in the SM structure and function (dysbiosis) are associated with several skin conditions. Therefore, novel target for the skincare field could be represented by strategies, which restore or preserve the SM natural/individual balance. Several of the beneficial effects exerted by the SM are aroused by the microbial metabolite butyrate. Since butyrate exerts a pivotal role in preserving skin health, it could be used as a postbiotic strategy for preventing or treating skin diseases. Herein, we describe and share perspectives of the potential clinical applications of therapeutic strategies using the postbiotic butyrate against human skin diseases.

【 授权许可】

Unknown