A good sugar, d-mannose, suppresses autoimmune diabetes

Cell & Bioscience

Deling Yin¹  Yun-Bo Shi² 

[1] Department of Internal Medicine, College of Medicine, East Tennessee State University;Molecular Morphogenesis, National Institute of Child Health and Human Development, National Institutes of Health;

关键词: Glucose;    Mannose;    Diabetes;    Autoimmune disease;    Inflammation;    Immunosuppression;   

DOI  :  10.1186/s13578-017-0175-1

来源: DOAJ

【 摘 要 】

Abstract It is well known that too much sugar uptake causes many health problems, including diabetes and obesity (Lustig et al. in Nature 482:27–29, 2012). However, a team of researchers led by Dr. Wanjun Chen of the National Institute of Dental and Craniofacial Research (NIDCR), National Institutes of Health (NIH), USA, have recently shown that d-mannose, a naturally occurring C-2 epimer of glucose is likely beneficial to human health. Their studies have revealed that supraphysiological levels of d-mannose that are safely achievable via drinking-water supplementation can be preventive and therapeutic to experimental autoimmune diabetes and asthmatic lung inflammation (Zhang et al. in Nat Med 23:1036–1045, 2017).

【 授权许可】

Unknown