Neuroprotective activity of Ipomoea cairica leaf extract against cadmium chloride-induced biochemical changes in the brain of male Wistar rats

Bulletin of the National Research Centre

Oghenetega J. Avwioroko¹  Temitope Temiloluwa Odewale²  Francis O. Atanu³  Mohammed Alqarni³  Omotayo B. Ilesanmi⁴  Gaber El-Saber Batiha⁵  Toyin Binang⁶  Ahmad J. Obaidullah⁶ 

[1] Department of Biochemistry, Faculty of Basic Medical Sciences, Redeemer’s University;Department of Biochemistry, Faculty of Life Science, University of Benin;Department of Biochemistry, Faculty of Natural Sciences, Kogi State University;Department of Biochemistry, Faculty of Science, Federal University Otuoke;Department of Pharmacology and Therapeutics, Faculty of Veterinary Medicine, Damanhour University;Lagoon School;

关键词: Cadmium;    Neurotoxicity;    Natural product;    Oxidative stress;    Beta-amyloid;    Glutamate;   

DOI  :  10.1186/s42269-022-00749-5

来源: DOAJ

【 摘 要 】

Abstract Background Exposure to cadmium is implicated in the etiology of some neurodegenerative diseases. Compounds isolated from Ipomoea cairica extract are neuroprotective. However, there is no reported neuroprotective activity of the crude extract of I. cairica (ICE). We investigated the neuroprotective activity of I. cairica extract against cadmium-induced biochemical changes in the brain of male Wistar rats. Thirty-six animals were divided into four groups of 9 animals per group: group I (Control); group II (3.5 mg/kg CdCl2); group III (100 mg/kg ICE + CdCl2); and group IV (250 mg/kg ICE + CdCl2). Animals were pretreated with 100 and 250 mg/kg ICE before co-administration with cadmium chloride. Results CdCl2 treatment caused a significant increase in acetylcholineesterase activity, lipid peroxidation, beta-amyloid aggregation, caspase 3 and 9, p53, and glutamate concentration. In addition, CdCl2 caused a significant decrease in catalase activity, superoxide dismutase, glutathione-S-transferase, Na+/K+ ATPase, and glutamate dehydrogenase. ICE was able to reduce the neuronal damaging effect of CdCl2 by acting as an antioxidant, antiapoptotic, anticholinesterase, and antiexcitotoxicity. Conclusions Our findings show that Ipomoea cairica leaf can be developed and included in the natural product in the prevention of neurodegenerative diseases.

【 授权许可】

Unknown