Diagnostic utility of adenosine deaminase in serum and bronchoalveolar lavage fluid for screening lung cancer in Western Iran

Journal of Medical Biochemistry

Sigari Naseh¹  Fathi Fardin¹  Ghaderi Bayazid¹  Mohsenpour Behzad¹  Azadi Namam-Ali¹  Nikkhoo Bahram²  Abdi Mohammad²  Afkhamzadeh Abdolrahim³ 

[1] Faculty of Medicine, Kurdistan University of Medical Sciences, Sanandaj, Iran;Faculty of Para Medicine, Kurdistan University of Medical Sciences, Sanandaj, Iran;Kurdistan University Research Center for Gastroenterology and Liver Disease, Kurdistan University of Medical Sciences, Sanandaj, Iran;

关键词: adenosine deaminase;    lung cancer;    serum;    bronchoalveolar lavage;    diagnostic value;   

DOI  :  

来源: DOAJ

【 摘 要 】

Background: This study aimed to determine adenosine deaminase (ADA) activity as a possible screening tool in lung cancer patients. Methods: Blood samples were collected from 30 subjects with positive pathological tests and 62 patients with negative pathological tests as a control group. The enzymatic activity of total ADA and its isoenzymes was determined. Results: tADA and ADA2 isoenzyme activity was significantly higher in cancerous patients compared to benign controls in serum and BAL fluid. Using a cut-off level of respectively 35.22 U/L and 31.80 U/L for BAL total ADA and ADA2, sensitivity and specificity were 100% and 81% for total ADA and 95% and 98% for ADA2. Conclusions: Adenosine deaminase may play important roles in the pathophysiology of lung cancer and because of its might be considered as a useful screening tool among the other markers in lung cancer diagnosis.

【 授权许可】

Unknown