Effect of gender, age and vaccine on reactogenicity and incapacity to work after COVID-19 vaccination: a survey among health care workers

BMC Infectious Diseases

Marzia Bonsignore¹  Cathrin Kodde²  Andreas Bollmann³  Sven Hohenstein³  Ralf Kuhlen⁴  Alexander Schröder⁵  Rosita Günther⁵  Corinna Glenz⁵  Martin Englisch⁵  Andreas Meier-Hellmann⁵  Irit Nachtigall⁶  Parviz Ahmad-Nejad⁷  Petra Thürmann⁸ 

[1] Center for Hygiene, Evangelische Kliniken Gelsenkirchen;Department of Pneumology, Lungenklinik Heckeshorn, Helios Klinikum Emil von Behring;Heart Center Leipzig at University of Leipzig and Leipzig Heart Institute;Helios Health GmbH;Helios Kliniken GmbH;Infectious Diseases, HELIOS Hospital Emil-Von-Behring;Institute for Medical Laboratory Diagnostics, Center for Clinical and Translational Research, Helios University Hospital Wuppertal, University of Witten/Herdecke;Philipp Klee-Institute for Clinical Pharmacology, Helios University Hospital Wuppertal;

关键词: Vaccination;    COVID-19;    Sex differences;    Circadian rhythm;    Reactogenicity;    Working capacity;   

DOI  :  10.1186/s12879-022-07284-8

来源: DOAJ

【 摘 要 】

Abstract Background The aim of our study was to assess the impact the impact of gender and age on reactogenicity to three COVID-19 vaccine products: Biontech/Pfizer (BNT162b2), Moderna (mRNA-1273) and AstraZeneca (ChAdOx). Additional analyses focused on the reduction in working capacity after vaccination and the influence of the time of day when vaccines were administered. Methods We conducted a survey on COVID-19 vaccinations and eventual reactions among 73,000 employees of 89 hospitals of the Helios Group. On May 19th, 2021 all employees received an email, inviting all employees who received at least 1 dose of a COVID-19 to participate using an attached link. Additionally, the invitation was posted in the group’s intranet page. Participation was voluntary and non-traceable. The survey was closed on June 21st, 2021. Results 8375 participants reported on 16,727 vaccinations. Reactogenicity was reported after 74.6% of COVID-19 vaccinations. After 23.0% vaccinations the capacity to work was affected. ChAdOx induced impairing reactogenicity mainly after the prime vaccination (70.5%), while mRNA-1273 led to more pronounced reactions after the second dose (71.6%). Heterologous prime-booster vaccinations with ChAdOx followed by either mRNA-1273 or BNT162b2 were associated with the highest risk for impairment (81.4%). Multivariable analyses identified the factors older age, male gender and vaccine BNT162b as independently associated with lower odds ratio for both, impairing reactogenicity and incapacity to work. In the comparison of vaccine schedules, the heterologous combination ChAdOx + BNT162b or mRNA-1273 was associated with the highest and the homologue prime-booster vaccination with BNT162b with the lowest odds ratios. The time of vaccination had no significant influence. Conclusions Around 75% of the COVID-19 vaccinations led to reactogenicity and nearly 25% of them led to one or more days of work loss. Major risk factors were female gender, younger age and the administration of a vaccine other than BNT162b2. When vaccinating a large part of a workforce against COVID-19, especially in professions with a higher proportion of young and women such as health care, employers and employees must be prepared for a noticeable amount of absenteeism. Assuming vaccine effectiveness to be equivalent across the vaccine combinations, to minimize reactogenicity, employees at risk should receive a homologous prime-booster immunisation with BNT162b2. Trial registration: The study was approved by the Ethic Committee of the Aerztekammer Berlin on May 27th, 2021 (Eth-37/21) and registered in the German Clinical Trials Register (DRKS 00025745). The study was supported by the Helios research grant HCRI-ID 2021-0272.

【 授权许可】

Unknown