Glioblastoma Microenvironment: From an Inviolable Defense to a Therapeutic Chance

Frontiers in Oncology

Enrico Franceschi¹  Stefania Bartolini¹  Alba Ariela Brandes¹  Alicia Tosoni¹  Vincenzo Di Nunno²  Lidia Gatto² 

[1] Nervous System Medical Oncology Department, IRCCS Istituto delle Scienze Neurologiche di Bologna, Bologna, Italy;Department of Oncology, AUSL Bologna, Bologna, Italy;

关键词: microenvironment;    glioblastoma;    macrophages;    neurons;    immune-system;   

DOI  :  10.3389/fonc.2022.852950

来源: DOAJ

【 摘 要 】

Glioblastoma is an aggressive tumor and is associated with a dismal prognosis. The availability of few active treatments as well as the inexorable recurrence after surgery are important hallmarks of the disease. The biological behavior of glioblastoma tumor cells reveals a very complex pattern of genomic alterations and is partially responsible for the clinical aggressiveness of this tumor. It has been observed that glioblastoma cells can recruit, manipulate and use other cells including neurons, glial cells, immune cells, and endothelial/stromal cells. The final result of this process is a very tangled net of interactions promoting glioblastoma growth and progression. Nonetheless, recent data are suggesting that the microenvironment can also be a niche in which glioblastoma cells can differentiate into glial cells losing their tumoral phenotype. Here we summarize the known interactions between micro-environment and glioblastoma cells highlighting possible therapeutic implications.

【 授权许可】

Unknown