Iron-catalyzed indolo[2,3-c]quinoline synthesis from nitroarenes and benzylic alcohols/aldehydes promoted by elemental sulfur

Green Synthesis and Catalysis

Guo-Jun Deng¹  Rong Li²  Haolin Zheng²  Shanping Chen²  Zhi Huang²  Hanwen Lei²  Shuxin Jiang² 

[1] Corresponding author.;Key Laboratory for Green Organic Synthesis and Application of Hunan Province, Key Laboratory of Environmentally Friendly Chemistry and Application of Ministry of Education, College of Chemistry, Xiangtan University, Xiangtan, 411105, China;

关键词: Iron-catalyzed;    Nitro reduction;    Alcohol oxidation;    Oxidative annulation;    Indolo[2,3-c]quinolines;   

DOI  :  

来源: DOAJ

【 摘 要 】

An iron-catalyzed strategy for the rapid synthesis of indolo[2,3-c]quinolines has been developed. This cascade reaction involving alcohol oxidation, nitro reduction, and oxidative annulation was achieved in a one-pot. The present protocol was started from mono-functionalized indoles and readily available benzylic alcohols/aldehydes, affording a variety of functionalized indolo[2,3-c]quinolines in satisfactory yields.

【 授权许可】

Unknown