Effect of opposing needling on motor cortex excitability in healthy participants and in patients with post-stroke hemiplegia: study protocol for a single-blind, randomised controlled trial

Trials

Jiahui Liu¹  Wenjuan Fan²  Yu Zhang³  Mindong Xu⁴  Jianlu Wu⁴  Yanling Yu⁴  Yinyu Zi⁴  Weifeng Wen⁵  Haofeng Mo⁵  Churong Liu⁵  Wei Yi⁶  Liming Lu⁶  Xiaorong Tang⁶  Nenggui Xu⁶  Lin Wang⁶ 

[1] College of Chinese Medicine, Guangzhou University of Chinese Medicine;College of Health Medicine, Chongqing Youth Vocational and Technical College;Massage Therapy Center, The First Affiliated Hospital of Anhui University of Chinese Medicine;Medical College of Acu-Moxi and Rehabilitation, Guangzhou University of Chinese Medicine;Rehabilitation Department, Guangdong 999 Brain Hospital;South China Research Center for Acupuncture and Moxibustion, Medical College of Acu-Moxi and Rehabilitation, Guangzhou University of Chinese Medicine;

关键词: Opposing needling;    Stroke;    Post-stroke hemiplegia;    Transcranial magnetic stimulation;    Resting motor threshold;    Motor-evoked potential;   

DOI  :  10.1186/s13063-021-05443-x

来源: DOAJ

【 摘 要 】

Abstract Background Opposing needling has an obvious curative effect in the treatment of post-stroke hemiplegia; however, the mechanism of the opposing needling in the treatment of post-stroke hemiplegia is still not clear. The purpose of this study is to investigate the effect of opposing needling on the excitability of primary motor cortex (M1) of healthy participants and patients with post-stroke hemiplegia, which may provide insight into the mechanisms of opposing needling in treating post-stroke hemiplegia. Methods This will be a single-blind, randomised, sham-controlled trial in which 80 healthy participants and 40 patients with post-stroke hemiplegia will be recruited. Healthy participants will be randomised 1:1:1:1 to the 2-Hz, 50-Hz, 100-Hz, and sham electroacupuncture groups. Patients with post-stroke hemiplegia will be randomised 1:1 to the opposing needling or conventional treatment groups. The M1 will be located in all groups by using neuroimaging-based navigation. The stimulator coil of transcranial magnetic stimulation (TMS) will be moved over the left and right M1 in order to identify the TMS hotspot, followed by a recording of resting motor thresholds (RMTs) and motor-evoked potentials (MEPs) of the thenar muscles induced by TMS before and after the intervention. The primary outcome measure will be the percent change in the RMTs of the thenar muscles at baseline and after the intervention. The secondary outcome measures will be the amplitude (μV) and latency (ms) of the MEPs of the thenar muscles at baseline and after the intervention. Discussion The aim of this trial is to explore the effect of opposing needling on the excitability of M1 of healthy participants and patients with post-stroke hemiplegia. Trial registration Chinese Clinical Trial Registry ChiCTR1900028138 . Registered on 13 December 2019.

【 授权许可】

Unknown