Expanding the role of interventional oncology for advancing precision immunotherapy of solid tumors

Molecular Therapy: Oncolytics

Yasushi Kimura¹  Govindarajan Srimathveeralli¹  Mario Ghosn²  Stephen B. Solomon²  Waseem Cheema³  Prasad S. Adusumilli³ 

[1] Department of Mechanical and Industrial Engineering, University of Massachusetts, Amherst, MA, USA;Interventional Radiology Service, Department of Radiology, Memorial Sloan Kettering Cancer Center, New York, NY, USA;Thoracic Service, Department of Surgery, Memorial Sloan Kettering Cancer Center, New York, NY, USA;

关键词: CAR T cell therapy;    interventional oncology;    interventional radiology;    locoregional cell delivery;    percutaneous ablation;    embolization;   

DOI  :  

来源: DOAJ

【 摘 要 】

Adoptive cell therapy with chimeric antigen receptors (CAR) T cells has proven effective for hematologic malignancies, but success in solid tumors has been impeded by poor intratumoral infiltration, exhaustion of effector cells from antigen burden, and an immunosuppressive tumor microenvironment. Results from recent clinical trials and preclinical studies lend promising evidence of locoregional approaches for CAR T cell delivery, priming the tumor microenvironment, and performing adjuvant therapies that sustain T cell activity. Interventional oncology is a subspeciality of interventional radiology where imaging guidance is used to perform percutaneous and catheter-directed procedures for localized, non-surgical therapy or interrogation of solid tumors. Interventional oncology provides unique synergies with immunotherapy, which has been well-studied to improve treatment efficacy while reducing toxicities associated with systemic treatment. Besides aiding in CAR T cell delivery, priming, or the stimulation of the tumor microenvironment to promote effector survival and function, interventional oncology can also aid in the monitoring of treatment response through selective, multiplex tumor sampling and catheter-based venous sampling. This review presents an overview of interventional oncology, its various procedures, and its potential for advancing CAR T cell immunotherapy of solid tumors.

【 授权许可】

Unknown