Sarcopenia Worsening One Month after Transarterial Radioembolization Predicts Progressive Disease in Patients with Advanced Hepatocellular Carcinoma

Biology

Quirino Lai¹  Leonardo Teodoli²  Claudio Trobiani²  Carlo Catalano²  Pierleone Lucatelli²  Giulio Eugenio Vallati³  Federico Cappelli³  Sara Ungania⁴ 

[1] Department of General Surgery and Organ Transplantation, Sapienza University of Rome, 00161 Rome, Italy;Department of Radiological Sciences, Oncology and Anatomical Pathology, Policlinico Umberto I, University of Rome “Sapienza”, 00161 Rome, Italy;Interventional Radiology Unit of “IRCCS Istituto Nazionale Tumori Regina Elena”, 00138 Rome, Italy;Physics Department of “Istituto Regina Elena, Istituto di Ricovero e Cura a Carattere Scientifico”, 00138 Rome, Italy;

关键词: TARE;    sarcopenia;    HCC;    interventional oncology;    liver;   

DOI  :  10.3390/biology10080728

来源: DOAJ

【 摘 要 】

(1) Background: To demonstrate correlation between skeletal muscle depletion measured before and after one month of TARE treatment and its induced local response rate. (2) Material and methods: For this retrospective, single center study, we evaluated 86 patients with HCC treated with TARE. Sarcopenia status was measured using the psoas muscle index (PMI). The PMI was calculated according to the formula: PMI [mm/m²]: [(minor diameter of left psoas + major diameter of left psoas + minor diameter of right psoas + major diameter of right psoas)/4]/height in m². Population was divided in two groups according to the delta value of PMI measured at the time of TARE and one month after TARE, a group in which the delta PMI was stable or increased (No-Sarcopenia group; n = 42) vs. a group in which the delta-PMI decreased (Sarcopenia group; n = 44). Patient response was evaluated at 1, 3 and 6 months after TARE treatment with CT/MRI. (3) Results: When the radiological response of the tumor was evaluated according to the mRECIST criteria, the two groups were similar in terms of rates of complete response (p = 0.42), partial response (p = 0.26) and stable disease (p = 0.59). Progressive disease (PD) was more commonly observed in the Sarcopenia group (38.6% vs. 11.9%; p = 0.006). (4) Conclusions: Worsening of sarcopenia status measured one month after TARE is able to predict patients who will undergo disease progression.

【 授权许可】

Unknown