BMC Genomics | |
Profiling microRNAs in lung tissue from pigs infected with |
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关键词: MicroRNA; RNAseq; High throughput sequencing; RT-qPCR; Actinobacillus pleuropneumoniae; Pig; Pleuropneumonia; | |
DOI : 10.1186/1471-2164-13-459 | |
来源: DOAJ |
【 摘 要 】
Abstract
Background
MicroRNAs (miRNAs) are a class of non-protein-coding genes that play a crucial regulatory role in mammalian development and disease. Whereas a large number of miRNAs have been annotated at the structural level during the latest years, functional annotation is sparse.
Results
In this study, the RNA extracted from visually unaffected and necrotic tissue from pigs infected with
Conclusions
This is the first study revealing significant differences in composition and expression profiles of miRNAs in lungs infected with a bacterial pathogen. Our results extend annotation of microRNA in pig and provide insight into the role of a number of microRNAs in regulation of bacteria induced immune and inflammatory response in porcine lung.
【 授权许可】
Unknown