Design, fabrication, and implantation of tube-shaped devices for the treatment of salivary duct diseases

BioImpacts

Alain Bizeau¹  Sofiane Guessasma²  Diego Velasquez²  Denis Lourdin²  Laurent Chaunier²  Graciela Pavon-Djavid³  Anne Meddahi-Pellé³  Frédéric Faure⁴ 

[1] Hôpital Sainte Musse, Service d’ORL et de Chirurgie Cervico-Faciale, Toulon, France;INRA, UR1268 Biopolymères Interactions Assemblages, Rue de la Géraudière, Nantes, 44316, France;INSERM, U1148 LVTS, Université Paris 13, Sorbonne Paris Cité 99 Ave Jean-Baptiste Clément, 93 430 Villetaneuse, France;Service ORL et CCF, Hôpital Edourad Herriot, CHU de Lyon, 69437 Lyon, France;

关键词: extrusion;    degradable device;    sialendoscopy;    starch;    tube;   

DOI  :  10.15171/bi.2018.11

来源: DOAJ

【 摘 要 】

Introduction: Starch-based materials were designed using a special extrusion die in order to obtain a tube-shaped device for application to salivary duct treatment in the field of endoscopy, i.e., sialendoscopy. Methods: Extrusion process was used to produce starch tubes. Mechanical properties of the dry tube before implantation were determined using an axial compression test. A finite element study was carried out to simulate the behavior of the hydrated tube under external axial pressure. Hydrolysis of these devices in a simulated salivary solution was studied, as well as its glycerol kinetics release. An animal short-term implantation model for salivary ducts was proposed as a feasibility study for starch tube-shaped devices.Results: A continuous production of regular and size-controlled tubes was obtained. The very small diameter obtained, less than 2 mm, corresponds to the requirement of being insertable in a human salivary duct using sialendoscopy guidewire. Finite element analysis showed that the starch tube can still support an external pressure higher than 0.2 MPa without irreversible damage. After 4 days of implantation, the host response is encouraging and the inflammatory response for this type of procedure remains normal. Conclusion: These devices were adapted to sialendoscopic guidewires and able to be implanted in the salivary ducts of pigs. If a longer lasting tube is required, the crystallinity of the starch material should be improved.

【 授权许可】

Unknown