Isoprostanes

Journal of Lipid Research

Ginger L. Milne¹  L. Jackson Roberts, II² 

[1] Division of Clinical Pharmacology, Vanderbilt University Medical Center, Nashville, TN;To whom correspondence should be addressed;

关键词: oxidative stress;    lipid peroxidation;    prostaglandins;   

DOI  :  

来源: DOAJ

【 摘 要 】

The isoprostanes (IsoPs) are a unique series of prostaglandin-like compounds formed in vivo via a nonenzymatic mechanism involving the free radical-initiated peroxidation of arachidonic acid. This article summarizes our current knowledge of these compounds. Herein, a historical account of their discovery and the mechanism of their formation are described. A specific class of IsoPs, the F2-IsoPs, are stable, robust molecules that can be measured as indices of endogenous oxidant stress. The utility of these molecules as biomarkers and methods by which these compounds can be quantified are discussed. In addition to the F2-IsoPs, isoprostanes with other prostane ring structures as well as oxidation products with furan and dioxolane rings can be generated from arachidonic acid. And, in more recent years, isoprostane-like compounds have been shown to be formed from polyunsaturated fatty acids including eicosapentaenoic acid [C20:5, ω-3], docosahexaenoic acid [C22:6, ω-3], and adrenic acid [C22:4, ω-6]. These findings will be summarized as well.

【 授权许可】

Unknown