Characteristics of 18F-FDG and 18F-FDOPA PET in an 8-year-old neutered male Yorkshire Terrier dog with glioma: long-term chemotherapy using hydroxyurea plus imatinib with prednisolone and immunoreactivity for PDGFR-β and LAT1

Veterinary Quarterly

Wonguk Lee¹  Dongwoo Chang²  Soochong Kim²  Sanggu Kim²  Byeong-Teck Kang³  Taesik Yun³  Yoonhoi Koo³  Mhan-Pyo Yang³  Hakhyun Kim³ 

[1] Department of Nuclear Medicine, Chungbuk National University Hospital;Department of Veterinary Medicine, College of Veterinary Medicine, Chungbuk National University;Laboratory of Veterinary Internal Medicine, College of Veterinary Medicine, Chungbuk National University;

关键词: dog;    canine;    18f-fdg;    18f-fdopa;    glioma;    hydroxyurea;    imatinib;    l-type amino acid transporter 1;    positron emission tomography;   

DOI  :  10.1080/01652176.2021.1906466

来源: DOAJ

【 摘 要 】

An 8-year-old neutered male Yorkshire Terrier dog presented with head pressing, vestibular ataxia, neck tenderness, and no oculocephalic reflex. A demarcated lesion in the pons was identified on MRI. The patient was tentatively diagnosed with a glioma and was treated with hydroxyurea plus imatinib and prednisolone. After 30 days of therapeutic treatment, the patient showed a clear improvement in neurological signs, which lasted for 1117 days. On day 569 after the initiation of treatment, 18F-fluorodeoxyglucose (FDG)-positron emission tomography (PET) was performed with no significant findings on visual analysis. The average and maximal standardized uptake values (SUVs) were 1.92 and 2.29, respectively. The tumor-to-normal-tissue (T/N) ratio was 0.97. The first evidence of clinical deterioration was noticed on day 1147. On day 1155, 3,4-dihydroxy-6-[18F]-fluoro-l-phenylalanine (18F-FDOPA)-PET was performed. High uptake of 18F-FDOPA was observed in the intracranial lesion. The mean and maximal SUVs of the tumor were 1.59 and 2.29, respectively. The T/N ratio was 2.22. The patient was euthanized on day 1155 and histopathologic evaluations confirmed glioma (astrocytoma). This case shows that chemotherapy with hydroxyurea plus imatinib may be considered in the treatment of canine glioma. Furthermore, this is the first case describing the application of 18F-FDG and 18F-FDOPA in a dog with glioma.

【 授权许可】

Unknown