Wound monitoring of pH and oxygen in patients after radiation therapy

Radiation Oncology

Stephan Schreml¹  Alexandra Blancke Soares²  Martin Canis²  Frank Haubner²  Steffen Auerswald³  Claus Belka⁴  Maximilian Niyazi⁴  Sebastian Marschner⁵  Robert Meier⁶ 

[1] Department of Dermatology, University Medical Center Regensburg;Department of Otorhinolaryngology, University Medical Center Munich, Klinikum Großhadern;Department of Otorhinolaryngology, University Medical Center Regensburg;Department of Radiation Oncology, University Medical Center Munich;German Cancer Consortium (DKTK), German Cancer Research Center (DKFZ);Presens;

关键词: Wound healing;    Radiotherapy;    Luminescence;    pH;    Oxygen;   

DOI  :  10.1186/s13014-019-1413-y

来源: DOAJ

【 摘 要 】

Abstract Objectives Postradiogenic wound healing disorders are an important clinical problem. While a variety of treatment modalities are available, there is no strategy to objectively judge treatment success. The aim of this study was to evaluate a 2D luminescence imaging system for pH and oxygen in non-healing wounds after radiotherapy. Methods Luminescence 2D imaging was performed with the VisiSens (Presens, Regensburg, Germany) 2D imaging systems A1 and A2 for oxygen and pH, respectively. Biocompatible planar luminescent sensor foils were applied to non-irradiated and irradiated skin as well as to radiogenic wounds of five patients and the pH and the oxygen saturation was determined. Results pH measurements showed significant differences between non-irradiated skin (6.46 ± 0.18) and irradiated skin (6.96 ± 0.26). Radiogenic wounds exhibited the highest pH values (7.53 ± 0.26). Oxygen measurements revealed a mean oxygen saturation of non-irradiated skin of 6.19 ± 0.83 mmHg. The highest value of oxygen saturation (28.4 ± 2.4 mmHg) was found on irradiated skin while irradiated wounds had a poor oxygen saturation (9.4 ± 2.2 mmHg) (mean ± s.e.m.). Conclusion We found that routine measurement of pH and pO2 in patients could be easily integrated into the clinical routine. The results of the measurements show unfavorable pH and oxygen saturation conditions for wound healing in irradiated wounds. Interestingly, irradiated wounds exhibit a more pronounced hypoxia than irradiated skin which is reflected by an altered pH and pO2 compared to unirradiated skin, which has the potential to serve as a prognostic marker in the future. In addition to the objectification of the treatment success of postradiogenic wound healing disorders, the extent of skin toxicity could already be predicted during radiotherapy with this method.

【 授权许可】

Unknown