Marine Indole Alkaloids—Isolation, Structure and Bioactivities

Marine Drugs

Siling Chen¹  Shuai Dong¹  Fang Yang¹  Yong Hu¹ 

[1] Key Laboratory of Tropical Biological Resources of Ministry of Education, School of Pharmaceutical Sciences, Hainan University, Haikou 570228, China;

关键词: marine alkaloids;    indoles;    natural products;    cytotoxicity;    antibacterial;    bioactivities;   

DOI  :  10.3390/md19120658

来源: DOAJ

【 摘 要 】

Indole alkaloids are heterocyclic natural products with extensive pharmacological activities. As an important source of lead compounds, many clinical drugs have been derived from natural indole compounds. Marine indole alkaloids, from unique marine environments with high pressure, high salt and low temperature, exhibit structural diversity with various bioactivities, which attracts the attention of drug researchers. This article is a continuation of the previous two comprehensive reviews and covers the literature on marine indole alkaloids published from 2015 to 2021, with 472 new or structure-revised compounds categorized by sources into marine microorganisms, invertebrates, and plant-derived. The structures and bioactivities demonstrated in this article will benefit the synthesis and pharmacological activity study for marine indole alkaloids on their way to clinical drugs.

【 授权许可】

Unknown