Long non-coding RNAs in the regulation of myeloid cells

Journal of Hematology & Oncology

Xinyi Tang¹  Shengjun Wang¹  Xinyu Tian¹  Jie Ma²  Jie Tian² 

[1] Department of Laboratory Medicine, The Affiliated People’s Hospital, Jiangsu University;Institute of Laboratory Medicine, Jiangsu Key Laboratory of Laboratory Medicine, School of Medicine, Jiangsu University;

关键词: Long non-coding RNAs;    Erythrocytes and megakaryocytes;    Granulocytes;    Monocytes and macrophages;    Cell development;   

DOI  :  10.1186/s13045-016-0333-7

来源: DOAJ

【 摘 要 】

Abstract Long non-coding RNAs (lncRNAs) have been attracting immense research interests. The relevance of lncRNAs in biological and physiological as well as in pathological processes has increased along with the understanding of their various regulatory mechanisms. Abundant studies have indicated that lncRNAs are involved in the differentiation, proliferation, activation, and initiation of apoptosis in different cell types. However, most studies about the regulating biology of lncRNAs are currently focused on cancer cells. This review is focused on the widely unexplored role of lncRNAs in the cell fate of myeloid cells. In this review, we summarize recent studies that have confirmed lncRNAs to be essential in the development of myeloid cells under normal and pathological conditions.

【 授权许可】

Unknown