The Role of Autophagy in Liver Epithelial Cells and Its Impact on Systemic Homeostasis

Nutrients

Sara Mandatori¹  Elio Ziparo¹  Eugenio Gaudio¹  Viviana Moresi¹  Claudia Giampietri¹  Simonetta Petrungaro¹  Federico Giulitti¹  Luana Tomaipitinca¹  Romina Mancinelli¹  Antonio Facchiano² 

[1] Department of Anatomical, Histological, Forensic Medicine and Orthopedic Sciences, Sapienza University of Rome, 00161 Rome, Italy;Laboratory of Molecular Oncology, Istituto Dermopatico dell’Immacolata, IDI-IRCCS, 00167 Rome, Italy;

关键词: autophagy;    liver;    lipid droplets;    metabolism;    oxidative stress;    cancer;   

DOI  :  10.3390/nu11040827

来源: DOAJ

【 摘 要 】

Autophagy plays a role in several physiological and pathological processes as it controls the turnover rate of cellular components and influences cellular homeostasis. The liver plays a central role in controlling organisms’ metabolism, regulating glucose storage, plasma proteins and bile synthesis and the removal of toxic substances. Liver functions are particularly sensitive to autophagy modulation. In this review we summarize studies investigating how autophagy influences the hepatic metabolism, focusing on fat accumulation and lipids turnover. We also describe how autophagy affects bile production and the scavenger function within the complex homeostasis of the liver. We underline the role of hepatic autophagy in counteracting the metabolic syndrome and the associated cardiovascular risk. Finally, we highlight recent reports demonstrating how the autophagy occurring within the liver may affect skeletal muscle homeostasis as well as different extrahepatic solid tumors, such as melanoma.

【 授权许可】

Unknown