The effects of pentoxifylline adminstration on fracture healing in a postmenopausal osteoporotic rat model

Laboratory Animal Research

Mohammad Mahdi Vashghani Farahani¹  Mohammad Bayat²  Mohammadamin Abdollahifar³  Reza Ahadi⁴ 

[1] Basic Sciences Department, Paramedical School, Shahid Beheshti University of Medical Sciences;Cellular and Molecular Biology Research Centre, Department of Anatomical Sciences and Biology, Medical School, Shahid Beheshti University of Medical Sciences;Department of Anatomical sciences and Biology, School of Medicine, Shahid Beheshti University of Medical Sciences;Department of Anatomy, School of medicine, Iran University of Medical Sciences;

关键词: Osteoporosis;    osteotomy;    ovariectomy;    femur;    hounsfield unit biomechanical phenomena;    rat;   

DOI  :  10.5625/lar.2017.33.1.15

来源: DOAJ

【 摘 要 】

Abstract Previous studies report positive effects of pentoxifylline (PTX) alone or in combination with other drugs on some pathologic bone diseases as well as an ability to accelerate osteogensis and fracture healing in both animal models and human patients. The aim of this present study was to evaluate the effects of PTX administration on Hounsfield unit and bone strength at catabolic response (bone resorbing) of a fracture in an experimental rat model of ovariectomy induced osteoporosis (OVX-D). Thirty adult female rats were divided into groups as follows: 1 (OVX, control, no treatment); 2 (OVX, sham: daily distilled water); 3 (OVX, daily alendronate: 3 mg/kg); 4 (OVX, twice daily 100 mg/kg PTX) and 5 (OVX, PTX+alenderonate). OVX was induced by bilateral ovariectomy in all rats. A complete standardized osteotomy of the right femur was made after 3.5 months. PTX and alendronate treatments were performed for eight weeks. Then, rats were euthanized and had its right femur subjected to computerized tomography scanning for measuring Hounsfield unit; eventually, the samples were sent for a three point bending test for evaluation of the bone strength. Administration of PTX with 200 mg/kg and alendronate alone and in combination showed no significant alteration in Hounsfield unit and biomechanical properties of repairing callus of the complete osteotomy compared with the control group. Results showed increased bending stiffness and stress high load mean values of repairing complete osteotomy in PTX-treated rats compared to the control OVX-D.

【 授权许可】

Unknown