The Different Facades of Retinal and Choroidal Endothelial Cells in Response to Hypoxia

International Journal of Molecular Sciences

Parviz Mammadzada¹  Effat Alizadeh¹  Helder André¹ 

[1] Department of Clinical Neuroscience, St. Erik Eye Hospital, Karolinska Institutet, 11282 Stockholm, Sweden;

关键词: choroidal endothelial cells;    retinal endothelial cells;    hypoxia;    angiogenesis;    differential expression;   

DOI  :  10.3390/ijms19123846

来源: DOAJ

【 摘 要 】

Ocular angiogenic diseases, such as proliferative diabetic retinopathy and neovascular age-related macular degeneration, are associated with severe loss of vision. These pathologies originate from different vascular beds, retinal and choroidal microvasculatures, respectively. The activation of endothelial cells (EC) plays pivotal roles in angiogenesis, often triggered by oxygen deficiency. Hypoxia-inducible factors in ECs mediate the transcription of multiple angiogenic genes, including the canonical vascular endothelial growth factors. ECs show notable heterogeneity in function, structure, and disease, therefore the understanding of retinal/choroidal ECs (REC; CEC) biochemical and molecular responses to hypoxia may offer key insights into tissue-specific vascular targeting treatments. The aim of this review is to discuss the differences spanning between REC and CEC, with focus on their response to hypoxia, which could provide innovative and sustainable strategies for site specific targeting of ocular neovascularization.

【 授权许可】

Unknown