Molecular-Level Interactions between Engineered Materials and Cells

International Journal of Molecular Sciences

Kwang-il Lim¹  Yoon-ha Jang¹  Xuelin Jin²  Kyubong Jo²  Prabakaran Shankar³  JungHeon Lee³ 

[1] Department of Chemical and Biological Engineering, Sookmyung Women’s University, Seoul 04310, Korea;Department of Chemistry and Integrated Biotechnology, Sogang University, Seoul 04107, Korea;School of Advanced Materials Science and Engineering, Sungkyunkwan University (SKKU), Suwon 16419, Korea;

关键词: mechanotransduction;    materials engineering;    cell surface sensors;    genome states;    cellular responses;   

DOI  :  10.3390/ijms20174142

来源: DOAJ

【 摘 要 】

Various recent experimental observations indicate that growing cells on engineered materials can alter their physiology, function, and fate. This finding suggests that better molecular-level understanding of the interactions between cells and materials may guide the design and construction of sophisticated artificial substrates, potentially enabling control of cells for use in various biomedical applications. In this review, we introduce recent research results that shed light on molecular events and mechanisms involved in the interactions between cells and materials. We discuss the development of materials with distinct physical, chemical, and biological features, cellular sensing of the engineered materials, transfer of the sensing information to the cell nucleus, subsequent changes in physical and chemical states of genomic DNA, and finally the resulting cellular behavior changes. Ongoing efforts to advance materials engineering and the cell−material interface will eventually expand the cell-based applications in therapies and tissue regenerations.

【 授权许可】

Unknown