The characteristics of 527 discharged COVID-19 patients undergoing long-term follow-up in China

International Journal of Infectious Diseases

Chunting Wang¹  Jiawei Xu¹  Liang Dong¹  Wei Zhang²  Yun Pan³  Ximing Wang⁴  Kang Ning⁵  Tian Liu⁶  Jintao Zhang⁷  Shengyu Zhou⁷  Jiping Zhao⁷ 

[1] Respiratory Department, Shandong Provincial Qianfoshan Hospital, Shandong University, The First Affiliated Hospital of Shandong First Medical University, Shandong Institute of Respiratory Diseases, Jinan, China;Department of Critical Care Medicine, Shandong Provincial Hospital Affiliated to Shandong First Medical University, Jinan, China;Department of Lung Disease, Affiliated Hospital of Shandong University of Traditional Chinese Medicine, Jinan, China;Department of Respiratory and Critical Care Medicine, Qilu Hospital, Cheeloo College of Medicine, Shandong University, Jinan, China;Radiology Department, Shandong Provincial Hospital Affiliated to Shandong First Medical University, Shandong University, Jinan, China;Respiratory Department, Shandong Provincial Qianfoshan Hospital, Shandong University, The First Affiliated Hospital of Shandong First Medical University, Shandong Institute of Respiratory Diseases, Jinan, China;Respiratory Department, Shandong Qianfoshan Hospital, Cheeloo College of Medicine, Shandong University, Jinan, China;

关键词: COVID-19;    Discharged patients;    Follow-up;    Imaging features;    Antibodies;   

DOI  :  

来源: DOAJ

【 摘 要 】

Background: Almost a year after the outbreak of coronavirus disease 2019 (COVID-19), many hospitalized COVID-19 patients have recovered. However, little is known about the long-term follow-up (> 2 months) of discharged patients. Methods: This study enrolled 527 discharged COVID-19 patients from 05 February to 11 March 2020. Basic characteristics, imaging features, nucleic acid detection results, and antibody levels of these patients were retrospectively reviewed. Results: Of the 527 discharged patients, 32 (6.1%) had re-detectable positive (RP) nucleic acid results for SARS-CoV-2 during follow-up examinations, with 11 and four detections entailing stool samples and anal swabs, respectively, rather than respiratory samples. Juveniles were more susceptible to “infection recurrence” than other age groups, with shorter time spans for re-detectable positive (RP) RNA tests (an average of 8.8 days [6.0–9.0 days]), while the reverse was true for the middle-aged group (17.5 days on average [14.0–17.5 days]). Similar improvements in the imaging features of both RP and no RP (NRP) groups were observed. Negative antibody detections in patients at 3 and 6 months after discharge were 14.2% and 25.0%, respectively. Cases evidencing negative antibodies were more common among juvenile patients (40% vs. 15.6%, P = 0.03) 6 months post-discharge. Conclusions: A total of 6.1% of 527 discharged patients showed RP status, which may be easier to be identified from stool samples than from other samples. Given the dropping rate of SARS-CoV-2 antibodies, reinfection may happen, especially in juvenile patients (aged < 18 years). These findings have implications for the long-term management of recovered COVID-19 patients.

【 授权许可】

Unknown